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The primary theoretical concern is that sustained NAD+ elevation through chronic NNMT inhibition could activate pathways (PARP, SIRT1) that have context-dependent roles in cancer biology NAD+ supports DNA repair and cellular longevity, but also fuels rapidly dividing cells

These can, in turn, facilitate the ease of engaging in physical activities, which form part of any weight reduction program

Most patients notice improved energy and mood within 48 hours, with many choosing to come in weekly for ongoing support

But there is no evidence yet that supplements can slow cognitive decline or prevent neurological issues